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CDP-Choline is a choline donor involved in the biosynthesis of brain phospholipids and acetylcholine, extensively used in the treatment of brain
enhancement.
Harvard Medical School StudyIn a study at the Harvard Medical School, healthy, older subjects who took 600 mg. of Memory Mender for six weeks had improved their scores on the California Verbal Learning Test. In the two controlled trials, daily doses of 1,200 mg of Memory Mender improved the immediate recall and attention in a group of young adult males (ages 19-38) compared with a placebo. In middle-aged and elderly subjects, Memory Mender supplementation improved reaction time by supporting energy generation and electrical coordination in the brain. CDP-Choline ...........................................650mg
This product is pure nutrition; no fillers, additives or synthetic chemicals. The gelatin capsule complies with the requirements published in: The United States Pharmacopoeia (USP); XXIV / National Formulary (NF) 19 Kosher and Halal certified Supplementation: More can be taken to enhance the effects. CDP-choline is safe, as toxicological tests have shown; it has no serious effects on the cholinergic system and it is perfectly tolerated. These pharmacological characteristics, combined with CDP-choline's mechanisms of action, suggest that this nutrient may be suitable for the treatment of cerebral vascular disease, head trauma of varying severity and cognitive disorders of diverse etiology. Most people find if they consume the product at night the product will help them sleep better. CDP-Choline helps the body make dopamine. CDP-choline stimulates tyrosine hydroxylase activity and dopamine release, which
increases in brain acetylcholine. Memory Mender will improve your memory within 30 days or your money back.Testimonials
Libby from Oregan:
Dear Customer Service, I have struggled for years with my mental abilities. I had trouble remembering and my thoughts were always a jumble. I constantly felt as if my mind was in a fog. I began taking BioAnue Memory Mender about 2 1/2 weeks ago and am amazed at the difference I have seen. I am thinking more clearly than ever before. I would recommend this product to anyone suffering from any cognitive problems. I recently ordered your Bio Anue Memory mender and began taking it about 30 days ago. This product is wonderful, I am so pleased with the results I have seen thus far and I plan on continuing to use this product. Thank you for making such a high quality product at such a great price. Mae from Georgia: I noticed a difference almost immediately. My cognitive abilities have sharpened and am able to recall events a lot easier. BioAnue Memory Mender is food for the brain. Thank You! James from Georgia: Dear Customer Service. Megan from Wisonsin: Dear Customer Service, Kelly: Dear Customer Service, Public speaking is a part of my job. After 3 years of taking BioAnue Memory Mender I do not have to study or practice my speeches as much as I used to. My memory retention is that of a 20 year old and not a 40 plus year old. Turning back the hands of time feels nice. I could not have done it without your quality product. I will be a lifelong user of this product that repairs and sustains the brain.
Phosphatidylcholine, common name lecithin, is usually the most abundant phospholipid in humans and plants, often amounting to almost 50% of the total, this is the key building block of membrane bilayers. In particular, it makes up a very high proportion of the outer leaflet of the plasma membrane. Phosphatidylcholine is also the principal phospholipid circulating in plasma, where it is an integral component of the lipoproteins, especially the HDL. Acetylcholine (pronounced: ah-see’-til-koh-leen):a nutrient in the brain that plays a key role in memory, learning, and many other brain functions. Research has indicated that lower levels of acetylcholine are associated with Alzheimer's disease. A neurotransmitter nutrient that allows nerve cells and muscles to communicate. Acetylcholine transmits signals from the nerve endings into the muscle, signaling the muscle to contract, this is believed to help healthy individuals improve coordination. Dopamine cannot cross the blood-brain barrier, dopamine synthetic given as a drug does not directly affect the central nervous system. To increase the amount of dopamine in the brains of patients with diseases such as Alzheimer’s, Stroke, or Parkinson's disease, CDP-Choline can be used, which is the precursor of dopamine. CDP-Choline can be given because it can cross the blood-brain barrier. Dopamine has many functions in the brain, including important roles:
Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, the substantia nigra pars compacta, and the arcuate nucleus of the hypothalamus. Dopamine Teaching SignalIn life, we learn to repeat behaviors that lead to maximize rewards. Dopamine is therefore believed to provide a teaching signal to parts of the brain responsible for acquiring new behavior. Temporal difference learning provides a computational model describing how the prediction error of dopamine neurons is used as a teaching signal. Age-related decreases in brain dopamine activity are associated with a decline in motor function and may also contribute to impaired performance on tasks that involve frontal brain regions. Interventions that enhance dopamine activity may improve performance and quality of life for the elderly. The fact that correlations remained significant after age effects were partialed out suggests that dopamine activity may influence motor and cognitive performance irrespective of age. CDP-choline, Cytidine 5'-diphosphocholine or citicoline, is an essential intermediate in the biosynthetic pathway of the structural phospholipids of cell membranes, especially in that of phosphatidylcholine. Oral AdministrationCDP-choline releases its two principle components, cytidine and choline. When administered orally, it is absorbed almost completely, and its bioavailability is approximately the same as when administered intravenously. BiopathwaysOnce absorbed, the cytidine and choline disperse widely throughout the organism, cross the blood-brain barrier and reach the central nervous system, where they are incorporated into the phospholipid fraction of the membrane and microsomes. CDP-choline activates the biosynthesis of structural phospholipids in the neuronal membranes, increases cerebral metabolism and acts on the levels of various neurotransmitters. Thus, it has been experimentally proven that CDP-choline increases noradrenaline, stimulates tyrosine hydroxylase activity and dopamine levels in the central nervous system, which increases in brain acetylcholine. NeuroprotectiveDue to these pharmacological activities, CDP-choline has a neuroprotective effect in situations of hypoxia and ischemia, as well as improved learning and memory performance in human and animal models of brain aging. Stimulatin Mitochondrial ActivityFurthermore, it has been demonstrated that CDP-choline restores the activity of mitochondrial ATPase and of membranal Na+/K+ ATPase, inhibits the activation of phospholipase A2 and accelerates the reabsorption of cerebral edema in various experimental models. CDP-choline is safe, as toxicological tests have shown; it has no serious effects on the cholinergic system and it is perfectly tolerated. These pharmacological characteristics, combined with CDP-choline's mechanisms of action, suggest that this nutrient may be suitable for the treatment of cerebral vascular disease, head trauma of varying severity and cognitive disorders of diverse etiology. Head TraumaIn studies carried out on the treatment of patients with head trauma, CDP-choline accelerated the recovery from post-traumatic coma and the recuperation of walking ability, achieved a better final functional result and reduced the hospital stay of these patients, in addition to improving the cognitive and memory disturbances which are observed after a head trauma of lesser severity and which constitute the disorder known as postconcussion syndrome Acute Cerebral Vascular Disease.In the treatment of patients with acute cerebral vascular disease of the ischemic type, CDP-choline accelerated the recovery of consciousness and motor deficit, attaining a better final result and facilitating the rehabilitation of these patients. Senile Cognitive ImpairmentThe other important use for CDP-choline is in the treatment of senile cognitive impairment, which is secondary to degenerative diseases (e.g., Alzheimer's disease) and to chronic cerebral vascular disease. In patients with chronic cerebral ischemia, CDP-choline improves scores on cognitive evaluation scales, while in patients with senile dementia of the Alzheimer's type, it slows the disease's evolution. Parkinson's diseaseBeneficial neuroendocrine, neuroimmunomodulatory and neurophysiological effects have been desescribed. CDP-choline has also been shown to be effective as co-therapy for Parkinson's disease.
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