Oxidation damage in the body has been demonstrated to be from glutathione deficiency causing gene expression damage.
Carcinogens are one of the key components in the development of cancer.
* Glutathione supplementation is helpful when exposed to carcinogenic materials such as the following:
- Tobacco (natural carcinogenic material)
- Benzene (synthetic carcinogenic material)
- Chemo Therapy Drugs (allopathic carcinogenic material)
TumorX L-Glutathione Anti-Carcinogenic Formula will repair the body by taking the toxic materials out of the cells, thus allowing the body to repair itself.
Glutathione is the most abundant active (low-molecular-weight chemical) compound. It is the major antioxidant agent found in human cells.
Human studies demonstrate that adequate protein nutrition is crucial for the maintenance of health. Protein also contains the highest levels of glutathione in the human diet.
TumorX L-Glutathione Anti-Carcinogenic Formula plays important roles in the following: antioxidant defense, nutrient metabolism, and regulation of cellular events including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction and immune response.
- Key Antioxidant
- Deficiency / Diseases
- Free Radical Scavengers:
Key Antioxidants in the body
Synergistic actions in scavenging free radicals is one of the keys to defeating your disease. There has been growing evidence over the past three decades showing that malnutrition of protein, selenium, and zinc lower the bodies defenses.
Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases. Peer reviewed literature indicates that dietary antioxidants are needed in preventing and curing many human diseases such as:
- Cancer
- Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/anti tumor defenses.
Cancer Letters 57: 91-94, 1991.
- Cachexia
- Kwashiorkor
- Hepatitis
- The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raised glutathione levels help restore liver function.
American Journal of gastroenterology 91: 2569-2573, 1996
- Seizure
- Antioxidant Functions
- Antioxidants are well documented and known to play vital roles in health maintenance and disease prevention. Glutathione is your cell's own major antioxidant.
Biochemical Pharmacology 47: 2114-2123, 1994.
- Alzheimer’s Disease
- Is accompanied by a precipitous fall in glutathione levels. Source : Journal of Clinical Epidemiology 47:1021-26,1994
- Parkinson’s Disease
- Is accompanied by a precipitous fall in glutathione levels. Source : Journal of Clinical Epidemiology 47:1021-26,1994
- Arteriosclerosis
- Is accompanied by a precipitous fall in glutathione levels. Source : Journal of Clinical Epidemiology 47:1021-26,1994
- Neurological Disease
- Low glutathione levels have been associated with neuro-degenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig's Disease), Alzheimer's and Parkinson's.
The Lancet 344: 796-798, 1994.
- Liver Disease
- Athletic Performance
- Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge.
Journal of Applied Physiology 87: 1381-1385, 1999.
- Cystic Fibrosis
- Sickle Cell Anemia
- HIV/ AIDS
- Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS.
Proceedings of the National Academy of Science, USA 94: 1967-72, 1997
- Heart Attack
- Stroke
- Digestive Disorders
- Glutathione protects the body from inflammation of gastritis, stomach ulcers,
pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn's dis-ease.
Gut 42: 485-492, 1998
- Anemia
- Kidney disease
- People affected by kidney failure or dialysis suffer from higher levels of oxidative stress and decreased glutathione levels.
Source : Nephron 61 :404-408,1992
- Restoring glutathione as a therapeutic strategy in chronic kidney disease
Nephrol Dial Transplant (2004) 19: 1951-1955 s
- Heart Disease, Stroke and Cholesterol
- Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes.
Nutrition Reviews 54: 1-30, 1996.
- Lung Disease
- Doctors have used glutathione-promoting drugs to treat many lung diseases
including asthma, chronic bronchitis and emphysema. New and potentially
therapeutic roles can be found for cigarette smoke damage, pulmonary
fibrosis and other illnesses.
American Journal of Medical Science 307:119-127, 1994
- Toxins, Pollution and Radiation
- Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer.
Annual Reviews of Biochemistry 52: 711-760, 1983
- Diabetes
- Diabetics are more prone to infections and circulatory problems leading
to heart disease, kidney failure and blindness. Glutathione protects
against the complications of diabetes.
Clinical Science 91:575-582, 1996
- Pregnancy, Lactation and Childbirth
- Glutathione's role in fetal and placental development is critical. It also acts in the placenta to detoxify pollutants before they can reach the developing child. Many complications of pregnancy have been linked with poor glutathione levels.
Early Human Development 37: 167-174, 199
- Glutathione
- Arginine
- Citrulline
- Taurine
- Creatine
- Selenium
- Zinc
- Vitamin E
- Vitamin C
- Vitamin A
- Tea Polyphenols
Understanding free radical biology
Understanding free radical biology is necessary for designing an optimal nutritional countermeasure against sun damage exposure, target radiotherapy, cell cytotoxicity, free radicals (e.g., superoxide, nitric oxide, and hydroxyl radicals) and other reactive species (e.g., hydrogen peroxide, peroxynitrite, and hypochlorous acid) which are produced in the body, primarily as a result of low oxygen metabolism.
Excess amounts of iron and vitamin C can gives rise to the oxidation of biomolecules and cell injury if the body does not contain a healthy amount of anti-oxidants.
Glutathion Stimulates The Cytokine Activities
Cytokines are made by many cells, the predominant producers are helper T cells (Th) and macrophages.
The largest group of cytokines stimulates immune cell proliferation and differentiation. This group includes Interleukin 1 (IL-1), which activates T cells; IL-2, which stimulates proliferation of antigen-activated T and B cells; IL-4, IL-5, and IL-6, which stimulate proliferation and differentiation of B cells; Interferon gamma (IFNg), which activates macrophages; and IL-3, IL-7 and Granulocyte Monocyte Colony-Stimulating Factor (GM-CSF), which stimulate hematopoiesis.
Selected Immune Cytokines and Their Activities* |
Cytokine |
Producing Cell |
Target Cell |
Function** |
GM-CSF |
Th cells |
progenitor cells |
growth and differentiation of monocytes and DC |
IL-1a
IL-1b |
monocytes
macrophages
B cells
DC |
Th cells |
co-stimulation |
B cells |
maturation and proliferation |
NK cells |
activation |
various |
inflammation, acute phase response, fever |
IL-2 |
Th1 cells |
activated T and B cells, NK cells |
growth, proliferation,
activation |
IL-3 |
Th cells
NK cells |
stem cells |
growth and differentiation |
mast cells |
growth and histamine release |
IL-4 |
Th2 cells |
activated B cells |
proliferation and differentiation
IgG1 and IgE synthesis |
macrophages |
MHC Class II |
T cells |
proliferation |
IL-5 |
Th2 cells |
activated B cells |
proliferation and differentiation
IgA synthesis |
IL-6 |
monocytes
macrophages
Th2 cells
stromal cells |
activated B cells |
differentiation into plasma cells |
plasma cells |
antibody secretion |
stem cells |
differentiation |
various |
acute phase response |
IL-7 |
marrow stroma
thymus stroma |
stem cells |
differentiation into progenitor B and T cells |
IL-8 |
macrophages
endothelial cells |
neutrophils |
chemotaxis |
IL-10 |
Th2 cells |
macrophages |
cytokine production |
B cells |
activation |
IL-12 |
macrophages
B cells |
activated Tc cells |
differentiation into CTL
(with IL-2) |
NK cells |
activation |
IFN-a |
leukocytes |
various |
viral replication
MHC I expression |
IFN-b |
fibroblasts |
various |
viral replication
MHC I expression |
IFN-g |
Th1 cells,
Tc cells, NK cells |
various |
Viral replication |
macrophages |
MHC expression |
activated B cells |
Ig class switch to IgG2a |
Th2 cells |
proliferation |
macrophages |
pathogen elimination |
MIP-1a |
macrophages |
monocytes, T cells |
chemotaxis |
MIP-1b |
lymphocytes |
monocytes, T cells |
chemotaxis |
TGF-b |
T cells, monocytes |
monocytes, macrophages |
chemotaxis |
activated macrophages |
IL-1 synthesis |
activated B cells |
IgA synthesis |
various |
proliferation |
TNFa |
macrophages, mast cells, NK cells |
macrophages |
CAM and cytokine expression |
tumor cells |
cell death |
TNF-b |
Th1 and Tc cells |
phagocytes |
phagocytosis, NO production |
tumor cells |
cell death |
* CTL: cytotoxic T lymphocytes; DC: dendritic cells; GM-CSF: Granulocyte-Monocyte Colony Stimulating Factor; IL: interleukin; IFN: Interferon; TGF: Tumor Growth Factor; TNF: Tumor Necrosis Factor.
** Italicized activities are inhibited.
Your immune system depends on glutathion to destroy and inhibit cancer cells. Other functions of glutathion are destroying virus and other microorganisms.
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